Understand RLS and how it is treated

Restless Legs Syndrome (RLS) is more than just an urge to move your legs. Symptoms often happen at night. Sometimes these symptoms interrupt sleep. Learn more about symptoms of RLS and potential treatment options.⁸

People with RLS often experience a range of symptoms. Uncomfortable sensations occur most often in the legs. People with RLS may describe symptoms as itching, pulling, gnawing, and the creepy-crawlies. Symptoms typically worsen at night. Moving the limbs may relieve the discomfort. This leads many patients to pace, kick, or turn frequently in bed, which can disturb sleep. Sleep disturbance may have an even broader impact on a patient’s life

RLS causes both sensory and sleep symptoms⁹

A group of researchers conducted a study that identiﬁed more than 400 people with RLS.⁹ Take the quiz below to see how your symptoms compare.

Symptoms of moderate-to-severe primary RLS can affect your quality of life. Uncomfortable feelings in your legs and the urge to move often occur in the late afternoon or evening. This can make it difficult to get enough sleep. You may feel tired or groggy the next day, which can cause difficulties in the following areas^8-10:

Memory: You may ﬁnd it hard to remember or learn new things¹⁰
Concentration: You may struggle to focus on tasks⁹
Mood: You may feel depressed or experience mood swings⁹
Daily tasks: You may have trouble completing daily tasks¹⁰
Social activities: Your social life and relationships may be affected¹⁰

RLS symptoms may affect you after bedtime. By causing the urge to move, RLS can disturb sleep and affect how you feel during the daytime.

Finding relief from your RLS symptoms^10,11

The right treatment can help you take control of your moderate-to-severe primary RLS. Managing triggers can also help.

Make sure all your healthcare providers know that you have RLS. Some medications can trigger symptoms.

Always take medications as prescribed by your healthcare professional.

Talk to your healthcare provider about doing some mild exercises, including stretching. More vigorous exercises can trigger symptoms.

Keep a diary to track when your symptoms are the worst, and share this with your healthcare provider.

Try avoiding caﬀeine, smoking, and alcohol, as these may trigger symptoms.

Tips and resources to help you stay on track with treatment

NEXT: Starting Horizant® for RLS

Important Safety Information for HORIZANT® (gabapentin enacarbil) Extended-Release Tablets

INDICATIONS

HORIZANT® (gabapentin enacarbil) is a prescription medicine used to:

treat adults with moderate to severe primary Restless Legs Syndrome (RLS). HORIZANT is not for people who need to sleep during the daytime and stay awake at night.

manage pain from damaged nerves (postherpetic neuralgia) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.

IMPORTANT SAFETY INFORMATION

Do not drive after taking your dose of HORIZANT until you know how it affects you, including the morning after you take it. Do not operate heavy machinery or do other dangerous activities until you know how HORIZANT affects you. HORIZANT can cause sleepiness, dizziness, slow thinking, and can affect your coordination. Ask your healthcare provider when it is okay to do these activities.

Do not take other medicines that make you sleepy or dizzy while taking HORIZANT without talking to your healthcare provider. Taking HORIZANT with these other medicines may make your sleepiness or dizziness worse.

HORIZANT may cause suicidal thoughts or actions in a very small number of people (about 1 in 500). Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

thoughts or actions about suicide, self-harm, or dying; attempt to commit suicide
new or worsening depression or anxiety; or feeling agitated
new or worse restlessness or panic attacks
new or worse trouble sleeping (insomnia); or irritability
acting aggressive, being angry, or violent; acting on dangerous impulses
an extreme increase in activity or talking (mania); other unusual changes in mood or behavior

Serious breathing problems. Serious breathing problems can occur when HORIZANT is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting HORIZANT or when the dose is increased. Get help right away if breathing problems occur.

Do not stop taking HORIZANT without first talking to your healthcare provider. Suicidal thoughts or actions can be caused by things other than medicines. If you have these thoughts or actions, your healthcare provider may check for other causes.

HORIZANT may cause a serious or life-threatening allergic reaction that may affect your skin or other parts of your body such as your liver or blood cells. You may or may not have a rash with these types of reactions. Call a healthcare provider right away if you have any of the following symptoms: skin rash, hives, fever, swollen glands that do not go away, swelling of your lips or tongue, yellowing of your skin or eyes, unusual bruising or bleeding, severe fatigue or weakness, unexpected severe muscle pain, or frequent infections. These symptoms may be the first signs of a serious reaction. A healthcare provider should examine you to decide if you should continue taking HORIZANT.

HORIZANT is not the same medicine as gabapentin [for example, NEURONTIN® (gabapentin) and GRALISE® (gabapentin)]. HORIZANT should not be used in their place. Do not take these or other gabapentin products while taking HORIZANT.

Before taking HORIZANT, tell your healthcare provider if you:

have or have had kidney problems or are on hemodialysis
have or have had depression, mood problems, or suicidal thoughts or behavior
have or have had seizures
have a history of drug abuse
have any other medical conditions
are pregnant or plan to become pregnant. It is not known if HORIZANT will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant while taking HORIZANT. You and your healthcare provider will decide if you should take HORIZANT while you are pregnant
are breastfeeding or plan to breastfeed. Your body turns HORIZANT into another drug (gabapentin) that passes into your milk. It is not known if this can harm your baby. You and your healthcare provider should decide if you will take HORIZANT or breastfeed
drink alcohol

Do not drink alcohol while taking HORIZANT because it may increase the risk of side effects.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking HORIZANT with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Do not stop taking HORIZANT without talking to your healthcare provider first. If you stop taking HORIZANT suddenly, you may develop side effects.

The most common side effects of HORIZANT include dizziness, sleepiness, and headache. Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of HORIZANT. For more information, ask your healthcare provider or pharmacist.

To report a possible side effect, contact Azurity Pharmaceuticals, Inc by email or phone at aereports@azurity.com (Adverse Event Report Form)/1-800-461-7449, or FDA at 1-800-FDA-1088 or www.fda.gov/MedWatch.

For more information, ask your healthcare provider or pharmacist, or consult the full Prescribing Information.

Understand RLS and how it is treated

What are the symptoms of RLS?8

RLS causes both sensory and sleep symptoms9

Finding relief from your RLS symptoms10,11